Research Assistant

Job description We are seeking a Research Assistant to support an investigation into whether it is possible to reverse hearing loss due to different types of pathology, and if so, to determine the limits of the critical period for intervention. Mice with primary defects in different inner ear structures will be used together with a genetic approach for activating expression of key genes after hearing loss has occurred. Structural and electrophysiological assays will be used to track changes in hearing function. The project requires experience in molecular biology and microscopy. Knowledge of either mouse genetics or auditory research would be an advantage but not essential. Good organisational and record-keeping skills are essential. This fixed-term position is funded by Wellcome until March 2026. The person appointed will report to Professor Karen P Steel at the Wolfson Centre for Age-Related Diseases, Guy’s Campus, near London Bridge. This post will be offered on a fixed-term contract until no later than March 2026, and the salary level will reflect relevant experience of the successful candidate. This is a full-time post - 100% full time equivalent

Key responsibilities

• Generate mice with required genotypes by managing breeding colonies and genotyping mice

• Carry out tests of auditory function as needed

• Analyse structural elements of the cochlea using confocal imaging or similar

• Carry out expression analysis

• Analyse findings and draft reports

• Take responsibility for general laboratory duties to support the team

• Train others in specialized techniques

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post. Skills, knowledge, and experience Essential criteria 1. Graduate in a relevant scientific field 2. Experience in laboratory research including molecular biology 3. Demonstrated experience in microscopy and imaging 4. Basic understanding of genetics 5. Willingness to work with mouse mutants 6. Evidence of good manual skills 7. Demonstrated good organizational skills and meticulous attention to detail 8. Adaptable and able to integrate with and support other lab members and work well in a team 9. Ability to work independently and troubleshoot technical problems 10. Ability to multitask and prioritise workload to fit external deadlines Desirable criteria

• Experience in whole animal studies

• Experience in laboratory management

• Experience in mouse colony management, genotyping and using databases